The effect of ibuprofen on muscle, hematological and renal function, hydric balance, pain, and performance during intense long-distance running

Copyright © 2019.
The purpose of this study was to research the effect of prophylactic use of antipsychotic anti inflammatory medication (NSAID, i.e. Ibuprofen) on physical operation, vertical jump, muscle biomarkers, liver, kidney, intense pain along with hydration status of participants in the 42 km Course Running Challenge, a long-distance race incorporated over mountain paths. The sample consisted of 20 men randomly divided in to two classes: a control group (CG) and an experimental group (EG) using 12 completing the race (41.1±8.8 y; 75.7±12.1 kilogram ) and within the last analysis. Even the EG were administered with an ibuprofen capsule (400 milligrams ) fifteen minutes ahead of the start of the race, and again after 5 hours of rushing if the road was not yet complete. There were significant time main effects for creatine kinase (CK) (p=0.001; f2 Cohen=0.25), lactate dehydrogenase (LDH) (p<0.001; f-2 Cohen=2.05), aspartate aminotransferase (AST) (p=0.002; f 2 Cohen=1.53), creatinine (p=0.002; f-2 Cohen=2.24), urea (p=0.001; f-2 Cohen=2.25), heart rate (HR) (p<0.001; f 2 Cohen=4.88) and pain scores (p<0.001; f2 Cohen=1.93) which increased throughout the race. There has been a group × period discussion for squat jump (SJ) which somewhat decreased in only the CG (p= 0.045; f 2 Cohen=2.17). This might have been linked to greater frequency of pain mentioned following the race at the gastrocnemius of the C G in comparison with the EG (p<0.05). It was concluded that ibuprofen intake didn't reduce muscle damage during the contest however maintained leg muscular power performance (i.e. vertical jump), maybe by lowering gastrocnemius muscle pain.
Raphael Fabrício p Souza Cidade Universitária Prof. José Aloísio de Campos Av. Marechal Rondon, s/n Jardim Rosa Elze CEP 49100-000 São Cristóvão/SE -LRB-79-RRB- 2105-6600, -LRB-79-RRB- 2105-6537 dihogogmc@hotmail.com

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